Clinical Trials

clinical trials

While the RLS Foundation does not conduct clinical trials, we do list clinical trial opportunities below and in our quarterly member magazine, NightWalkers. If you are interested in participating in a study, please scroll down to contact the researcher listed below. Clinical trials are research studies that enlist volunteers to investigate specific health questions. When carefully conducted, they are the fastest and safest way to find treatments that actually work for people. When you volunteer for a restless legs syndrome (RLS) clinical trial, you explore emerging treatment options for yourself while actively contributing to the advancement of RLS research. If you are a researcher who would like to include your study in our listings, please contact us at All studies must be approved by the Institutional Review Board (IRB) to qualify. There is no charge to publish a listing. In accordance with our corporate relations policy, the RLS Foundation does not endorse or sponsor any products or services.

Current Clinical Trials

December 2019

Hormones and Their Role in Restless Legs Syndrome

Researchers at Yale University are conducting research to determine whether specific stress hormone levels are increased in the blood and cerebrospinal fluid of persons with RLS. This study requires a one-time visit to New Haven, Connecticut, you will be reimbursed for the COST OF YOUR TRAVEL (up to $600).

Contact: Your first contact can be via email to Nada Ahmed at or call (203) 785-7393.

Full Clinical Trial Details

September 2019

Investigational Nerve Stimulation Device funded by Noctrix Health

You may qualify if you are 18 to 75 years old and have RLS symptoms. If you qualify as a study participant, you will be compensated up to $400 for your participation. Enrolling in the San Francisco Bay Area Only.

Full Clinical Trial Details

July 2019

Wearable Compression Vibratory Device—Adults (18 and over)

Two-month investigational study to test a wearable compression vibratory device for patients with Restless Legs Syndrome. If you qualify as a study participant, you will receive all study related materials at no cost and be paid for your time upon completion of all study requirements. Enrolling in the San Francisco Bay area only.

Contact: Ryan McCormick at CA Center for Sleep Disorders: 510-263-3331 or

Full Clinical Trial Details

February 2019

Well-Being and Health in RLS

Restless Legs Syndrome (RLS) is a condition associated with significant lifestyle changes. Researchers at Yale University are conducting a study that looks at health and well-being in patients with RLS.

Contact: Nada Ahmed at

Full Clinical Trial Details

October 2018

RLS & My Teen: What’s Next? — Fight RLS with Science

Find out about a study that’s for adolescents age 13-17 dealing with RLS and living in California, Florida, Illinois, New Jersey, New York, and Texas. Compensation available.

Call: (310) 464-2190

Full Clinical Trial Details


March 2016

Does your child have discomfort in their legs that may interfere with their sleep? Worldwide Clinical Trials is conducting research studies to test an investigational medication for the treatment of adolescent RLS.

Worldwide Clinical Trial

Contact: Camilla Alexander, (520) 252-1908,

Full Clinical Trial Details

January 2013

Determining whether there are changes in the retinal structure of the eyes of individuals with RLS compared to individuals with Parkinson’s disease, multiple system atrophy, and healthy controls.

New York University Langone Medical Center

Contact: Dr. Jose Martinez,

Full Clinical Trial Details

Further Reading

Clinical Trials

Clinical Trials: What to Know Before You Go

Inside: Important Information for those considering clinical trail participation

Read More