Clinical Trials

clinical trials

While the RLS Foundation does not conduct clinical trials, we do list clinical trial opportunities below and in our quarterly member newsletter, NightWalkers. If you are interested in participating in a study, please scroll down to contact the researcher listed below. Clinical trials are research studies that enlist volunteers to investigate specific health questions. When carefully conducted, they are the fastest and safest way to find treatments that actually work for people. When you volunteer for a restless legs syndrome (RLS) clinical trial, you explore emerging treatment options for yourself while actively contributing to the advancement of RLS research. If you are a researcher who would like to include your study in our listings, please contact us at All studies must be approved by the Institutional Review Board (IRB) to qualify. There is no charge to publish a listing.

Current Clinical Trials

February 2019

Well-Being and Health in RLS

Restless Legs Syndrome (RLS) is a condition associated with significant lifestyle changes. Researchers at Yale University are conducting a study that looks at health and well-being in patients with RLS.

Contact: Nada Ahmed at

Full Clinical Trial Details

October 2018

RLS & My Teen: What’s Next? — Fight RLS with Science

Find out about a study that’s for adolescents age 13-17 dealing with RLS and living in California, Florida, Illinois, New Jersey, New York, and Texas. Compensation available.

Call: (310) 464-2190

Full Clinical Trial Details

December 2017

Opioid Use to Treat RLS - CLOSING June 25, 2019

Dr. John Winkelman is building an RLS Opioid Registry based at Massachusetts General Hospital with patients from across the United States to assess the long-term safety and effectiveness of opioid medications for RLS.

How can you participate?

Contact: Julia Purks, (617) 643-2082 or email

Note: We will not be providing any consultation, advice about clinical care, or medication through this study.

Full Clinical Trial Details

March 2016

Does your child have discomfort in their legs that may interfere with their sleep? Worldwide Clinical Trials is conducting research studies to test an investigational medication for the treatment of adolescent RLS.

Worldwide Clinical Trial

Contact: Camilla Alexander, (520) 252-1908,

Full Clinical Trial Details

January 2013

Determining whether there are changes in the retinal structure of the eyes of individuals with RLS compared to individuals with Parkinson’s disease, multiple system atrophy, and healthy controls.

New York University Langone Medical Center

Contact: Dr. Jose Martinez,

Full Clinical Trial Details

Further Reading

Clinical Trials

Clinical Trials: What to Know Before You Go

Inside: Important Information for those considering clinical trail participation

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