Clinical Trials

clinical trials

While the RLS Foundation does not conduct clinical trials, we do list clinical trial opportunities below and in our quarterly member magazine, NightWalkers. If you are interested in participating in a study, please scroll down to contact the researcher listed below. Clinical trials are research studies that enlist volunteers to investigate specific health questions. When carefully conducted, they are the fastest and safest way to find treatments that actually work for people. When you volunteer for a restless legs syndrome (RLS) clinical trial, you explore emerging treatment options for yourself while actively contributing to the advancement of RLS research. If you are a researcher who would like to include your study in our listings, please contact us at All studies must be approved by the Institutional Review Board (IRB) to qualify. There is no charge to publish a listing. In accordance with our corporate relations policy, the RLS Foundation does not endorse or sponsor any products or services.

Current Clinical Trials

September 2021

Investigational wearable device to treat RLS

Noctrix Health is sponsoring a clinical research study for patients who have been diagnosed with restless legs syndrome (RLS). The study will be enrolling men and women, ages 22-79, who have tried at least one prescription medication for RLS but still have symptoms. You will be compensated for your time and travel.

Contact: Please visit for more information and to see if you might qualify.

Full Clinical Trial Details


August 2021

Insomnia after RLS is Under Control

Many people continue to experience insomnia even though their RLS is under good control. John W. Winkelman, MD, PhD, with the Sleep Disorders Clinical Research Program, Massachusetts General Hospital (MGH), is conducting a research study, performed virtually by video and/or phone, investigating the efficacy of an FDA-approved sleep medication (suvorexant, Belsomra) for the treatment of such people.

Contact: Jordana Zackon at 617-643-6026 or

Full Clinical Trial Details

March 2020

Understanding the Role of Epigenetics in RLS

Researchers at Johns Hopkins School of Medicine, led by Christopher J Earley MB,BCh, PhD, are conducting a study designed to address the question of why does RLS have such a high inheritance risk. If you are a woman who currently has iron deficiency anemia then you may be eligible for this study. We are looking for women who do and do not (control group) have RLS symptoms.

Contact: Jessica at 410-550-1046

Full Clinical Trial Details

March 2020

Intravenous Iron Therapy in Patients with Anemia and RLS

Researchers at Johns Hopkins School of Medicine, led by Christopher J Earley MB,BCh, PhD, are conducting a a clinical trial to establish the effectiveness of intravenous iron in treating patients who have an anemia and who also have RLS symptoms. If you currently have an iron deficiency anemia and have frequent RLS symptoms then you may be eligible for this clinical trial.

Contact: Jessica at 410-550-1046

Full Clinical Trial Details

December 2019

Hormones and Their Role in Restless Legs Syndrome

Researchers at Yale University are conducting research to determine whether specific stress hormone levels are increased in the blood and cerebrospinal fluid of persons with RLS. This study requires a one-time visit to New Haven, Connecticut, you will be reimbursed for the COST OF YOUR TRAVEL (up to $600).

Contact: Your first contact can be via email to Brian Koo, MD at or call (203) 785-4261

Full Clinical Trial Details

October 2018

RLS & My Teen: What’s Next? — Fight RLS with Science

Find out about a study that’s for adolescents age 13-17 dealing with RLS. Compensation available.

Call: (310) 464-2190

Full Clinical Trial Details


January 2013

Determining whether there are changes in the retinal structure of the eyes of individuals with RLS compared to individuals with Parkinson’s disease, multiple system atrophy, and healthy controls.

New York University Langone Medical Center

Contact: Dr. Jose Martinez,

Full Clinical Trial Details

Further Reading

Clinical Trials

Clinical Trials: What to Know Before You Go

Inside: Important Information for those considering clinical trail participation

Read More