Clinical Trials

While the RLS Foundation does not conduct clinical trials, we do list clinical trial opportunities below and in our quarterly member magazine, NightWalkers. If you are interested in participating in a study, please scroll down to contact the researcher listed below. Clinical trials are research studies that enlist volunteers to investigate specific health questions. When carefully conducted, they are the fastest and safest way to find treatments that actually work for people. When you volunteer for a restless legs syndrome (RLS) clinical trial, you explore emerging treatment options for yourself while actively contributing to the advancement of RLS research. If you are a researcher who would like to include your study in our listings, please contact us at info@rls.org. All studies must be approved by the Institutional Review Board (IRB) to qualify. There is no charge to publish a listing. In accordance with our corporate relations policy, the RLS Foundation does not endorse or sponsor any products or services.

Current Clinical Trials

March 2020

Understanding the Role of Epigenetics in RLS

Researchers at Johns Hopkins School of Medicine, led by Christopher J Earley MB,BCh, PhD, are conducting a study designed to address the question of why does RLS have such a high inheritance risk. If you are a woman who currently has iron deficiency anemia then you may be eligible for this study. We are looking for women who do and do not (control group) have RLS symptoms.

Contact: Jessica at 410-550-1046

Full Clinical Trial Details

March 2020

Intravenous Iron Therapy in Patients with Anemia and RLS

Researchers at Johns Hopkins School of Medicine, led by Christopher J Earley MB,BCh, PhD, are conducting a a clinical trial to establish the effectiveness of intravenous iron in treating patients who have an anemia and who also have RLS symptoms. If you currently have an iron deficiency anemia and have frequent RLS symptoms then you may be eligible for this clinical trial.

Contact: Jessica at 410-550-1046

Full Clinical Trial Details

December 2019

Hormones and Their Role in Restless Legs Syndrome

Researchers at Yale University are conducting research to determine whether specific stress hormone levels are increased in the blood and cerebrospinal fluid of persons with RLS. This study requires a one-time visit to New Haven, Connecticut, you will be reimbursed for the COST OF YOUR TRAVEL (up to $600).

Contact: Your first contact can be via email to Nada Ahmed at or call (203) 785-7393.

Full Clinical Trial Details

September 2019

Investigational Nerve Stimulation Device funded by Noctrix Health

You may qualify if you are 18 to 75 years old and have RLS symptoms. If you qualify as a study participant, you will be compensated up to $400 for your participation. Enrolling in the San Francisco Bay Area Only.

Contact:For more information, please contact the sleep laboratory at 650-859-4532 or sleep@sri.com

Full Clinical Trial Details

July 2019

Wearable Compression Vibratory Device—Adults (18 and over)

Two-month investigational study to test a wearable compression vibratory device for patients with Restless Legs Syndrome. If you qualify as a study participant, you will receive all study related materials at no cost and be paid for your time upon completion of all study requirements. Enrolling in the San Francisco Bay area only.

Contact:Ryan McCormick at CA Center for Sleep Disorders: 510-263-3331 or rmccormick@sleepdx.com

Full Clinical Trial Details

October 2018

RLS & My Teen: What’s Next? — Fight RLS with Science

Find out about a study that’s for adolescents age 13-17 dealing with RLS and living in California, Florida, Illinois, New Jersey, New York, and Texas. Compensation available.

Visit: www.science37.net/rls-teens
Call: (310) 464-2190
Email: RLSstudy@science37.com

Full Clinical Trial Details

March 2016

Does your child have discomfort in their legs that may interfere with their sleep? Worldwide Clinical Trials is conducting research studies to test an investigational medication for the treatment of adolescent RLS.

Worldwide Clinical Trial

Contact: Camilla Alexander, (520) 252-1908, Camilla.Alexander@wwctrials.com

Full Clinical Trial Details

January 2013

Determining whether there are changes in the retinal structure of the eyes of individuals with RLS compared to individuals with Parkinson’s disease, multiple system atrophy, and healthy controls.

New York University Langone Medical Center

Contact: Dr. Jose Martinez, Jose.Martinez@nyumc.org

Full Clinical Trial Details