Clinical Trials
While the RLS Foundation does not conduct clinical trials, we do list clinical trial opportunities below and in our quarterly member magazine, NightWalkers. If you are interested in participating in a study, please scroll down to contact the researcher listed below. Clinical trials are research studies that enlist volunteers to investigate specific health questions. When carefully conducted, they are the fastest and safest way to find treatments that actually work for people. When you volunteer for a restless legs syndrome (RLS) clinical trial, you explore emerging treatment options for yourself while actively contributing to the advancement of RLS research. If you are a researcher who would like to include your study in our listings, please contact us at info@rls.org. All studies must be approved by the Institutional Review Board (IRB) to qualify. There is no charge to publish a listing. In accordance with our corporate relations policy, the RLS Foundation does not endorse or sponsor any products or services.
December 2019
Hormones and Their Role in Restless Legs Syndrome
Researchers at Yale University are conducting research to determine whether specific stress hormone levels are increased in the blood and cerebrospinal fluid of persons with RLS. This study requires a one-time visit to New Haven, Connecticut, you will be reimbursed for the COST OF YOUR TRAVEL (up to $600).
Contact: Your first contact can be via email to Nada Ahmed at or call (203) 785-7393.
Full Clinical Trial Details
Investigational Nerve Stimulation Device funded by Noctrix Health
You may qualify if you are 18 to 75 years old and have RLS symptoms. If you qualify as a study participant, you will be compensated up to $400 for your participation. Enrolling in the San Francisco Bay Area Only.
Full Clinical Trial Details
July 2019
Wearable Compression Vibratory Device—Adults (18 and over)
Two-month investigational study to test a wearable compression vibratory device for patients with Restless Legs Syndrome. If you qualify as a study participant, you will receive all study related materials at no cost and be paid for your time upon completion of all study requirements. Enrolling in the San Francisco Bay area only.
Contact: Ryan McCormick at CA Center for Sleep Disorders: 510-263-3331 or rmccormick@sleepdx.com
Full Clinical Trial Details
February 2019
Well-Being and Health in RLS
Restless Legs Syndrome (RLS) is a condition associated with significant lifestyle changes. Researchers at Yale University are conducting a study that looks at health and well-being in patients with RLS.
Visit: https://yalesurvey.ca1.qualtrics.com/jfe/form/SV_4I7rXK9CXrA7wwt
Contact: Nada Ahmed at nada.ahmed@yale.edu
Full Clinical Trial Details
RLS & My Teen: What’s Next? — Fight RLS with Science
Find out about a study that’s for adolescents age 13-17 dealing with RLS and living in California, Florida, Illinois, New Jersey, New York, and Texas. Compensation available.
Visit: www.science37.net/rls-teens
Call: (310) 464-2190
Email: RLSstudy@science37.com
Full Clinical Trial Details
March 2016
Does your child have discomfort in their legs that may interfere with their sleep? Worldwide Clinical Trials is conducting research studies to test an investigational medication for the treatment of adolescent RLS.
Worldwide Clinical Trial
Contact: Camilla Alexander, (520) 252-1908, Camilla.Alexander@wwctrials.com
Full Clinical Trial Details
January 2013
Determining whether there are changes in the retinal structure of the eyes of individuals with RLS compared to individuals with Parkinson’s disease, multiple system atrophy, and healthy controls.
New York University Langone Medical Center
Contact: Dr. Jose Martinez, Jose.Martinez@nyumc.org
Full Clinical Trial Details
Further Reading
Clinical Trials: What to Know Before You Go
Inside: Important Information for those considering clinical trail participation
Read More